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The role of nanotechnologies is increasingly important in our society; their use has marked the beginning of a new era, like the press and Internet. The implications in the near future are many and surprising, from energy to environment, from medicine to building sector, from engineering to transport and telecommunications. It is a scientific and technological challenge, which requires work coordination of projects and available resources. The eco-innovation is a theme in evolution, as a frontier of new materials, innovative production methods (Green Technologies) and purchasing (Green Procurement), innovations in the transportation of people and goods, the opportunities offered by ICT world. In addition we will consider also open questions about the effects of nanotechnology on human health and the environment and the multidisciplinary research work required for supporting regulatory actions.